Systems Biology of Human RNA Regulatory Networks

RNA metabolism is a function of multiple interdependent regulatory processes orchestrated by ribonucleoprotein complexes (RNPs). RNPs regulate every aspect of RNA metabolism, including the transcription, splicing, poly-adenylation, export and localization, stability, and translation. Interdependent RNA metabolic processes coordinate the precise spatial and temporal expression patterns of mature RNA products, which have profound implications for human diseases. The overarching goal of my research is to quantitatively decipher the mysteries of human RNA regulatory networks, particularly as they relate to human disease.